Innovation is essential for the improvement of global public health and multilateral institutions are increasingly influential drivers of innovation policy. This panel is composed of a series of presentations that examine how the U.S. Government engages multilateral institutions and encourages innovative public health interventions, programs and research. The presentations will discuss the different structures of multilateral institutions, including the World Health Organization, the G-8, the African Union, Global Fund and UNAIDS, their ability to pass and implement innovation resolutions, and the United States Government's role in the implementation and shaping of policy in the multilateral arena.